Publication
2019.05 – 2024.12 Broad Institute of MIT and Harvard (Postdoc, Mentor: Dr. Feng Zhang)
Faure, G.*, Saito, M.*, Wilkinson, M. E.*, Quinones-Olvera, N., Xu, P., Flam-Shepherd, D., Kim, S., Reddy, N., Zhu, S., Evgeniou, L., Koonin, E. V., Macrae, R. K. and Zhang, F. (*equal contribution)
TIGR-Tas: A family of modular RNA-guided DNA-targeting systems in prokaryotes and their viruses.
Science, Online ahead of print., 2025.
Xu, P.*, Saito, M.*, Faure, G., Maguire, S., Vo, S., Wilkinson, M. E., Kuang, H., Wang, B., Rice, W. J., Macrae, R. K. and Zhang, F. (*equal contribution)
Structural insights into the diversity and DNA cleavage mechanism of Fanzor.
Cell 187, 5238-5252, 2024.
Saito, M.*, Xu, P.*, Faure, G., Maguire, S., Kannan, S., Altae-Tran, H., Vo, S., Desimone, A., Macrae, R. K. and Zhang, F. (*equal contribution)
Fanzor is a eukaryotic programmable RNA-guided endonuclease.
Nature 620, 660-668, 2023.
Faure, G.*, Saito, M.*, Benler, S.*, Peng, I.*, Wolf, Y. I., Strecker, J., Altae-Tran, H., Neumann, E., Li, D., Makarova, K. S., Macrae, R. K., Koonin, E. V. and Zhang, F. (*equal contribution)
Modularity and diversity of target selectors in Tn7 transposons.
Mol. Cell 83, 2122-2136, 2023.
Kreitz, J., Friedrich, M. J., Guru, A., Lash, B., Saito, M., Macrae, R. K. and Zhang, F.
Programmable protein delivery with a bacterial contractile injection system.
Nature 616, 357-364, 2023.
Saito, M.*, Ladha, A.*, Strecker, J.*, Faure, G.*, Neumann, E., Altae-Tran, H., Macrae, R. K. and Zhang, F. (*equal contribution)
Dual modes of CRISPR-associated transposon homing.
Cell 184, 2441-2453, 2021.
Joung, J., Ladha, A., Saito, M., Kim, N. G., Woolley, A. E., Segel, M., Barretto, R. P. J., Ranu, A., Macrae, R. K., Faure, G., Ioannidi, E. I., Krajeski, R. N., Bruneau, R., Huang, M.W., Yu, X.G., Li, J. Z., Walker, B. D., Hung, D. T., Greninger, A. L., Jerome, K. R., Gootenberg, J. S., Abudayyeh, O. O. and Zhang, F.
Detection of SARS-CoV-2 with SHERLOCK One-Pot Testing.
N. Engl. J. Med. 383, 1492-1494, 2020.
2013.06 – 2019.03 Friedrich Miescher Institute (Ph.D. student, Mentor: Dr. Patrick Matthias)
Saito, M., Iestamantavicius, V., Hess, D. and Matthias, P.
Monitoring Acetylation of the RNA Helicase DDX3X, a Protein Critical for Formation of Stress Granules.
In: Boudvillain M. (eds) RNA Remodeling Proteins. Methods in Molecular Biology vol 2209, 217-234, 2021. Humana, New York, NY.
Ustinova, K., Novakova, Z., Saito, M., Meleshin, M., Mikesova, J., Kutil, Z., Baranova, P., Havlinova, B., Schutkowski, M., Matthias, P. and Barinka, C.
The disordered N-terminus of HDAC6 is a microtubule-binding domain critical for efficient tubulin deacetylation.
J. Biol. Chem. 295, 2614-2628, 2020.
Saito, M., Hess, D., Eglinger, J., Fritsch, A. W., Kreysing, M., Weinert, B. T., Choudhary, C. and Matthias, P.
Acetylation of intrinsically disordered regions regulates phase separation.
Nat. Chem. Biol. 15, 51-61, 2019. (*Greatest hits, Nat. Chem. Biol. 16, 600–603 (2020))
Miyake, Y. Keusch, J. J., Wang, L., Saito, M., Hess, D., Wang, X., Melancon, B. J., Helquist, P., Gut, H. and Matthias, P.
Structural insights into HDAC6 tubulin deacetylation and its selective inhibition.
Nat. Chem. Biol. 12, 748-754, 2016. (*Greatest hits, Nat. Chem. Biol. 16, 600–603 (2020))
2011.04 – 2012.09 Waseda University (Master’s student, Mentor: Dr. Kentaro Semba)
Saito, M., Kato, Y., Ito, E., Fujimoto, J., Ishikawa, K., Doi, A., Kumazawa, K., Matsui, A., Takebe, S., Ishida, T., Azuma, S., Mochizuki, H., Kawamura, Y., Yanagisawa, Y., Honma, R., Imai, J., Ohbayashi, H., Goshima, N., Semba, K. and Watanabe, S.
Expression screening of 17q12-21 amplicon reveals GRB7 as an ERBB2-dependent oncogene.
FEBS lett. 586(12), 1708-14, 2012.
Yamamoto, T., Saito, M., Kumazawa, K., Doi, A., Matsui, A., Takebe, S., Amari, T., Oyama, M. and Semba, K.
ErbB2/HER2: Its contribution to basic cancer biology and the development of molecular targeted therapy.
In: Gunduz M, editor. Breast cancer – Carcinogenesis, Cell Growth and Signalling Pathways. InTech; pp. 139–70, 2011.